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Xiaoshan Ke, Abhimanyu Thakur, and Huanhuan Joyce Chen
Citaton (Review Article): StemJournal, Vol.4, Iss.1, pp. 1–11, 2022 (DOI: 10.3233/STJ-200003)
"Transdifferentiation into neuronal cells, skeletal myocytes, cardiac myocytes, and hematopoietic cells have been explored massively. Mature protocols existed for in vitro conversion from mouse and human cell sources; however, more investigation is needed for in vivo cases. Researchers have put extensive efforts into improving conversion efficiency by either overexpressing different transcription factors, transducing miRNAs into the system, or incorporating small molecules. Facilitating the next-generation biotechnologies and illustrating the signaling pathway behind each cell fate decision helps us recognize the critical factors and manipulate the transdifferentiation results."