Biotechnology is the science of applied biological process that blends natural science and engineering to comprehend and control biology at the molecular level for a profound impact. It accomplishes gene recombination, cloning of living things, and splicing of genes from the DNA of one organism into the genome of unrelated species. It plays a significant role in bio-agriculture, genomics, biochips, medicines, robotic military, bioinformatics, the biotech industry, stem cell research, fingerprinting, and bio-manufacturing which is essential for improving national security. Modern biotechnology is a multidisciplinary field and has proven a miracle for militaries from both; an offensive and defensive standpoint. Biotechnology has both prospects and constraints. Bio-weapons lead to disasters more dangerous than nuclear accidents. The database freely available on the internet has the potential for the development of a wide range of novel pathogens that can attack the plant, animal, and human populations worldwide. Biotechnology has created amazing possibilities and brought radical changes for the military in bio-armory, bio-sensors, biocomputing, bioengineered materials, biofuels, and biomimetics. This article highlights aspects of biotechnology as an evolving dimension of security, legal defense mechanisms, collaboration, and adherence of different concerned authorities, and analyzes ways to counter different threats of a bioweapon and boost national security. Nevertheless, it is clear biotechnology will be as important to consumer economics in the next century as physics and chemistry were in the last century.